Also the occurrence of infected plantar, palmar, and corneal ulceration was monitored, together with occurrence of TB. Major adverse events were defined as psychosis, peptic ulcer, glaucoma, cataract, diabetes and hypertension. Minor adverse events were defined as moon face, severe fungal infections, severe acne, and gastric pain requiring antacid.
ELE EXIBIA EM INGLES TRIAL
Treatment was with prednisolone according to fixed schedules for 16 weeks, starting in one trial with 20 nig/day (prophylactic regimen: total dosage 1.96 g) and in the other two trials with 40 mg/day (therapeutic regimen: total dosage 2.52 g). Methods: A multicentre, randomised, double-blind placebo-controlled trial was conducted in leprosy control programmes in Nepal and Bangladesh.
Safety concerns led to an assessment of adverse events of corticosteroids in three trials studying prevention of NFI (the TRIPOD study). The NetherlandsĪim: Reactions in leprosy causing nerve function impairment (NFI) are increasingly treated with standardised regimens of corticosteroids, often under field conditions. A case report on one patient who had a protracted illness and extended stay in the hospital is also presented.Ĭonclusion: These observations will assist in the clinical management of DHS, and aid its early diagnosis.ĪDVERSE EVENTS OF STANDARDISED REGIMENS OF CORTICOSTEROIDS FOR PROPHYLAXIS AND TREATMENT OF NERVE FUNCTION IMPAIRMENT IN LEPROSY: RESULTS FROM THE 'TRIPOD' TRIALS. Eighty per cent of cases recovered fully within one month of starting treatment. All were treated with prednisolone after immediate withdrawal of dapsone. The patients presented with a variety of symptoms, the most common of which was dermatitis (74%). Time of presentation was usually within 3 months of starting MDT (5 at 3m).
ELE EXIBIA EM INGLES SERIES
Results: Thirty-seven of those affected by DHS in our series were male and 17 female. Data of medical history was collected by a review of medical records charts. Methods: A retrospective study was carried out of a large series of 54 patients affected by leprosy 47 MB and 7 PB, diagnosed with DHS in the past 11 years. It can be very distressing to the patient and in severe forms can even lead to death.Īim: To review a large series of DHS patients, to be able to recognize and treat this effectively at its initial stages.
E-mail: Hypersensitivity Syndrome (DHS) is an important although rare complication seen in the treatment of leprosy. Maria Jacob K., Murdo Macdonald and Ruth Butlin.Īnandaban Leprosy Hospital, PO Box 151, Kathmandu, NEPAL. A LARGE SERIES OF DAPSONE HYPERSENSITIVITY SYNDROME PATIENTS IN NEPAL
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